Naukovi Novyny, Vol 2, Issue 4, April 30, 2020
ACE2, spikes, hydroxychloroquine and dogs
ACE2, spikes, hydroxychloroquine and dogs
D. Demydenko (editor)
D. Demydenko (editor)
As of April 29, 2020, about 3 million people were diagnosed with COVID-19 (COrona VIrus Disease 2019) and about 200 thousands died with the diagnosed presence of coronavirus SARS-CoV-2 (also known as 2019-nCoV) [1].
As of April 29, 2020, about 3 million people were diagnosed with COVID-19 (COrona VIrus Disease 2019) and about 200 thousands died with the diagnosed presence of coronavirus SARS-CoV-2 (also known as 2019-nCoV) [1].
The cell surface receptor protein or "lock" or "gate" through which SARS-CoV-2 enters cells is called ACE2 (angiotensin-converting enzyme 2). One part of ACE2 is an enzyme that cuts off the terminal components of some protein molecules, such as angiotensin, to function in deactivating them. But this is not the only ACE2 function, as it interacts not only with angiotensin, and it also has another part that performs the function of transporting certain molecular components. In general, the function of ACE2 is not fully known. In the human body, ACE2 is present in the kidneys, lungs, gastrointestinal tract, brain [2] and, according to some unconfirmed data, on the inner surface of the nasal cavity. Multifunctionality, due to the above mentioned features, is the basis for ACE2 involvement, among other things, in the regulation of blood pressure, metabolism in the kidneys and lungs, heart and the central nervous system function [2].
The cell surface receptor protein or "lock" or "gate" through which SARS-CoV-2 enters cells is called ACE2 (angiotensin-converting enzyme 2). One part of ACE2 is an enzyme that cuts off the terminal components of some protein molecules, such as angiotensin, to function in deactivating them. But this is not the only ACE2 function, as it interacts not only with angiotensin, and it also has another part that performs the function of transporting certain molecular components. In general, the function of ACE2 is not fully known. In the human body, ACE2 is present in the kidneys, lungs, gastrointestinal tract, brain [2] and, according to some unconfirmed data, on the inner surface of the nasal cavity. Multifunctionality, due to the above mentioned features, is the basis for ACE2 involvement, among other things, in the regulation of blood pressure, metabolism in the kidneys and lungs, heart and the central nervous system function [2].
That is, SARS-CoV-2, using the "key", its spike glycoprotein, can penetrate wherever ACE2 is present and directly or indirectly disrupt the functioning of many organs of the human body [3].
That is, SARS-CoV-2, using the "key", its spike glycoprotein, can penetrate wherever ACE2 is present and directly or indirectly disrupt the functioning of many organs of the human body [3].
